Quantitative determination of Dapoxetine Hydrochloride and Tadalafil using different validated spectrophotometric methods

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Dutasteride and tamsulosin combination is used to treat men who have symptoms of an enlarged prostate gland, which is also known as benign prostatic hyperplasia (BPH). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder.

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These products are synthetic antiandrogen that is used for the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).

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CAS registry number (Chemical Abstracts Service)

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Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

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BJU Int.

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Development and validation of HPTLC method for simultaneous estimation of sildenafil citrate and dapoxetine hydrochloride in combined dosage form

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Gowri sankar and co-authors, UV spectrophotometric method for the estimation of tadalafil in bulk and tablet dosage form

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Parameter Dapoxetine Tadalafil
Absorption Rapid; peak in 1-3 hours Peak in 2 hours
Bioavailability Approximately 54% About 84%
Metabolism Liver via CYP2D6 & CYP3A4 Liver via CYP3A4
Half-life 1-1.5 hours 17.5 hours
Excretion Urine and feces Mainly feces