Supplements to consider

Sildenafil is a great option when you need a one-night fix for ED. Like all ED medications, sildenafil can cause side effects like: Our guide to sildenafil side effects goes into more detail and covers potential drug interactions to be aware of if you’re considering taking it as an ED or PE treatment.

Medication Monitoring

Want to learn more about this ED medication? ED isn’t the only sexual health issue that can mess with your sex life. Research in the Indian Journal of Urology concluded that up to 39 percent of men may experience premature ejaculation at some point in their lives. Looking to tackle PE and boost your sexual confidence and stamina? You’ve got some solid options, including some of the prescription antidepressants and topical products outlined below.

Vitamin E

Sertraline (generic Zoloft®) is a selective serotonin reuptake inhibitor (SSRI) that healthcare professionals typically prescribe to treat major depressive disorder. They may also prescribe it off-label to help with increasing ejaculation latency, which is a clinical term for the time it takes before you reach orgasm and ejaculate. You can take it daily or just when you need it for PE. Thanks to its long-lasting effects, you can easily time your dose before getting intimate for the best results. There’s also a link between the other SSRIs and better sexual stamina, including: Research shows that all of these SSRIs may improve ejaculation time, with only mild side effects.

A note about sex and gender

Sprays, creams, and wipes might not be sex pills, but they can help treat premature ejaculation. Take our Clockstopper Benzocaine Wipes and Clockstopper Climax Delay Condoms, for example. They contain the topical anesthetic benzocaine that can reduce penis sensitivity. Just apply these products 10 to 15 minutes before sexual activity. You’ll last longer without feeling numb or uncomfortable. Tadalafil (Cialis) is a longer-lasting ED pill (up to 36 hours per dose).

• Combining medications should only be done under medical supervision.
• Side effects of ED pills include headaches and nasal congestion.
• Natural supplements may cause allergic reactions in some users.
• Overuse of stimulant-based products can lead to health risks.
• Consultation with a healthcare provider ensures safe treatment.
• Monitoring for adverse effects is vital when using ED pills.
• Not all pills work equally; efficacy varies among individuals.
• Some herbal supplements may interact with medications.
• Regular medical check-ups improve safety and effectiveness.
• Using counterfeit medications risks serious health complications.
• Ensuring dosage adherence prevents unnecessary side effects.
• Report any unexpected reactions to your doctor promptly.

That quality has earned it the nickname “the weekend pill” for ED.

Tadalafil is an excellent choice if you enjoy spontaneous sex or engage in sexual activity more than once a day.

Improve Sleep Quality

Sildenafil is a great option when you need a one-night fix for ED. Like all ED medications, sildenafil can cause side effects like: Our guide to sildenafil side effects goes into more detail and covers potential drug interactions to be aware of if you’re considering taking it as an ED or PE treatment. Tadalafil (Cialis) is a longer-lasting ED pill (up to 36 hours per dose). That quality has earned it the nickname “the weekend pill” for ED. Tadalafil is an excellent choice if you enjoy spontaneous sex or engage in sexual activity more than once a day.

Try Herbal Supplements

It can be taken as needed before sex or daily. Since it lasts long, you don’t need to worry about timing your dose. Side effects may stick around longer than other medications. Vardenafil (Levitra) is similar to sildenafil, but its effects last slightly longer, providing relief from ED for up to six hours. It might be a better option for you if you usually take your ED medication with or after dinner, since food is less likely to mess with its absorption.

Vitamin B Complex (B6, B9, B12)

Common side effects of vardenafil include headaches, nasal congestion, flushing, and indigestion—similar to other ED pills. Avanafil, sold under the brand name Stendra, is a newer ED medication with several benefits over other prescription pills: Avanafil starts to work in as little as 15 minutes so that you can take it closer to sex than other ED medications. Avanafil starts to work in as little as 15 minutes so that you can take it closer to sex than other ED medications. Like vardenafil, you can take avanafil with meals without slowing the onset. Stendra is less likely to cause side effects than other ED medications. It can be taken as needed before sex or daily. Since it lasts long, you don’t need to worry about timing your dose. Side effects may stick around longer than other medications. Vardenafil (Levitra) is similar to sildenafil, but its effects last slightly longer, providing relief from ED for up to six hours. It might be a better option for you if you usually take your ED medication with or after dinner, since food is less likely to mess with its absorption. Common side effects of vardenafil include headaches, nasal congestion, flushing, and indigestion—similar to other ED pills. Avanafil, sold under the brand name Stendra, is a newer ED medication with several benefits over other prescription pills: Avanafil starts to work in as little as 15 minutes so that you can take it closer to sex than other ED medications. Avanafil starts to work in as little as 15 minutes so that you can take it closer to sex than other ED medications.

2. Ashwagandha

Full Name: Lynn Marie Morski, MD, JD Full Name: Lynn Marie Morski, MD, JD Current Role at Hims & Hers: Medical Advisor Current Role at Hims & Hers: Medical Advisor Education: Juris Doctor - Thomas Jefferson School of Law, 2014 Doctor of Medicine - Saint Louis University School of Medicine, 2005 Juris Doctor - Thomas Jefferson School of Law, 2014 Juris Doctor - Thomas Jefferson School of Law, 2014 Doctor of Medicine - Saint Louis University School of Medicine, 2005 Doctor of Medicine - Saint Louis University School of Medicine, 2005 Training: Primary Care Sports Medicine Fellowship - University of Arizona, 2009 Family Medicine Residency - Mayo Clinic - 2008 Primary Care Sports Medicine Fellowship - University of Arizona, 2009 Primary Care Sports Medicine Fellowship - University of Arizona, 2009 Specialties & Areas of Focus: Mental Health, Primary Care, Psychedelic Medicine Previous Work Experience: Physician & Subinvestigator/Clinician Rater - Kadima Neuropsychiatry Institute, January 2025– Investigator - Elite Clinical Network, June 2024– Physician - Veterans Administration, 2010–2019 Physician & Subinvestigator/Clinician Rater - Kadima Neuropsychiatry Institute, January 2025– Physician & Subinvestigator/Clinician Rater - Kadima Neuropsychiatry Institute, January 2025– Invited Commentary on Psychedelic Therapy: A Primer for Primary Care Clinicians. Like vardenafil, you can take avanafil with meals without slowing the onset. Stendra is less likely to cause side effects than other ED medications.

Want to learn more about this ED medication?

• Psychological factors like stress impact libido significantly.
• Counseling may help resolve underlying emotional issues.
• Building confidence improves sexual desire and performance.
• Partner intimacy exercises can strengthen connection and desire.
• Sexual education enhances understanding and reduces anxiety.
• Mind-body techniques can boost libido naturally.
• Managing relationship conflicts supports healthy sex drive.
• Support groups provide emotional assistance for sexual health issues.
• Setting realistic expectations reduces pressure and enhances satisfaction.
• Focus on emotional intimacy to increase physical desire.
• Practice mindfulness during intimacy for heightened arousal.
• Regular sexual activity maintains and stimulates libido.

ED isn’t the only sexual health issue that can mess with your sex life. Research in the Indian Journal of Urology concluded that up to 39 percent of men may experience premature ejaculation at some point in their lives. Looking to tackle PE and boost your sexual confidence and stamina? You’ve got some solid options, including some of the prescription antidepressants and topical products outlined below. Sertraline (generic Zoloft®) is a selective serotonin reuptake inhibitor (SSRI) that healthcare professionals typically prescribe to treat major depressive disorder. They may also prescribe it off-label to help with increasing ejaculation latency, which is a clinical term for the time it takes before you reach orgasm and ejaculate. You can take it daily or just when you need it for PE. Thanks to its long-lasting effects, you can easily time your dose before getting intimate for the best results. There’s also a link between the other SSRIs and better sexual stamina, including: Research shows that all of these SSRIs may improve ejaculation time, with only mild side effects. Sprays, creams, and wipes might not be sex pills, but they can help treat premature ejaculation. Take our Clockstopper Benzocaine Wipes and Clockstopper Climax Delay Condoms, for example. They contain the topical anesthetic benzocaine that can reduce penis sensitivity. Just apply these products 10 to 15 minutes before sexual activity.

What to Watch For

Looking for men enhancement pills a sex pill with natural ingredients? You might be considering dietary supplements like ashwagandha, ginseng, or horny goat weed, which claim to improve sexual function by either amping up your sexual desire or triggering an erection. Some of these products even claim to assist with penis enlargement. Though they promise a lot, they’re not backed by much scientific evidence. Most of the studies supporting these claims involve animals, not humans, or have other problems.

Improve Relationships

Here’s a breakdown of what the research says about natural remedies for ED and PE: Studies show that ashwagandha can increase testosterone levels, but its effects on sex drive and male sexual health may not be much better than a placebo. Studies show that ashwagandha can increase testosterone levels, but its effects on sex drive and male sexual health may not be much better than a placebo. Some research shows that taking Asian ginseng may improve sexual function in men with ED, but it’s unclear how safe the herb is for long-term use. This natural ingredient contains icariin, a mild PDE5 inhibitor, which works similarly to prescription ED meds. However, most research on the herb has been conducted on animals.

Address Underlying Health Issues

More research on humans is needed to understand its effects on male sexual health. You can learn more about herbs, vitamins, and other men’s sexual health supplements in our guide to natural home remedies for ED. The aforementioned PDE5 inhibitors boost blood flow to your penis by blocking the PDE5 enzyme. Since erections are all about healthy blood flow, these drugs make it easier for you to get and stay hard when you’re in the mood for sex. As a reminder, FDA-approved PDE5 inhibitors include: Avanafil (a newer medication sold as Stendra®) Avanafil (a newer medication sold as Stendra®) Unlike gas station sex pills that overpromise and underdeliver, genuine ED treatments actually work. You’ll last longer without feeling numb or uncomfortable. Looking for men enhancement pills a sex pill with natural ingredients? You might be considering dietary supplements like ashwagandha, ginseng, or horny goat weed, which claim to improve sexual function by either amping up your sexual desire or triggering an erection. Some of these products even claim to assist with penis enlargement. Though they promise a lot, they’re not backed by much scientific evidence.

Most of the studies supporting these claims involve animals, not humans, or have other problems. Here’s a breakdown of what the research says about natural remedies for ED and PE: Studies show that ashwagandha can increase testosterone levels, but its effects on sex drive and male sexual health may not be much better than a placebo. Studies show that ashwagandha can increase testosterone levels, but its effects on sex drive and male sexual health may not be much better than a placebo. Some research shows that taking Asian ginseng may improve sexual function in men with ED, but it’s unclear how safe the herb is for long-term use.

2. Maca

For instance, a study revealed that 98.4 percent of men with erectile dysfunction who took sildenafil reported better erections. ED and PE medications work well on their own, but they’re more effective when combined with a healthy lifestyle. Simple habits like staying active can support healthy blood vessels and improve blood flow to your penis, helping you get and stay hard. To get the best results from ED pills, try incorporating the following habits into your routine: Exercise multiple times a week to reduce your risk of developing diabetes, which is a major risk factor for ED Exercise multiple times a week to reduce your risk of developing diabetes, which is a major risk factor for ED Eat a balanced diet that’s high in complex carbs, lean proteins, and fibrous vegetables Eat a balanced diet that’s high in complex carbs, lean proteins, and fibrous vegetables Limit foods that can impact heart health and blood pressure, like those high in saturated fat Limit foods that can impact heart health and blood pressure, like those high in saturated fat Quit smoking, which can damage your heart, lungs, and blood vessels, affecting your sexual performance Quit smoking, which can damage your heart, lungs, and blood vessels, affecting your sexual performance Limit your alcohol intake, which can cause “whiskey dick,” a non-clinical term for the negative effects of alcohol on healthy erections Limit your alcohol intake, which can cause “whiskey dick,” a non-clinical term for the negative effects of alcohol on healthy erections You can learn more about maintaining a better lifestyle for your sexual health in our full guide to maintaining an erection naturally. Around 30 to 50 million men in the United States deal with some level of erectile dysfunction.

A Safer Solution

Fortunately, there are many FDA-approved prescription medications that treat ED and other sexual health issues like premature ejaculation. Let’s recap what you should know about sex pills for men: “Sex pills” and penis enlargement pills are readily available, but they’re not all effective. Over-the-counter pills and supplements for sex aren’t backed by the same research as prescription medications. “Sex pills” and penis enlargement pills are readily available, but they’re not all effective. Some OTC options could actually be unsafe.

FYI on ED

FDA investigations have found that many sex pills for men contain hidden ingredients, including some that can result in dangerous drug interactions and other health problems. FDA-approved medications are your best bet for treating ED. Evidence-based PDE5 inhibitors like sildenafil and tadalafil can help with sexual health issues. They’re also available as chewable ED medications, which contain the same ingredients as Viagra and Cialis in personalized dosages. While they’re not approved for ED or PE, doctors sometimes prescribe SSRIs off-label for sexual dysfunction. This natural ingredient contains icariin, a mild PDE5 inhibitor, which works similarly to prescription ED meds. However, most research on the herb has been conducted on animals. More research on humans is needed to understand its effects on male sexual health. You can learn more about herbs, vitamins, and other men’s sexual health supplements in our guide to natural home remedies for ED.

Natural performance boosters

National Center for Complementary and Integrative Health. Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double blind study. Erectogenic and Neurotrophic Effects of Icariin, a Purified Extract of Horny Goat Weed (Epimedium spp.) In Vitro and In Vivo. Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation? Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: A multi-center study. The aforementioned PDE5 inhibitors boost blood flow to your penis by blocking the PDE5 enzyme. Since erections are all about healthy blood flow, these drugs make it easier for you to get and stay hard when you’re in the mood for sex. As a reminder, FDA-approved PDE5 inhibitors include: Avanafil (a newer medication sold as Stendra®) Avanafil (a newer medication sold as Stendra®) Unlike gas station sex pills that overpromise and underdeliver, genuine ED treatments actually work. For instance, a study revealed that 98.4 percent of men with erectile dysfunction who took sildenafil reported better erections.

ED and PE medications work well on their own, but they’re more effective when combined with a healthy lifestyle. Simple habits like staying active can support healthy blood vessels and improve blood flow to your penis, helping you get and stay hard. To get the best results from ED pills, try incorporating the following habits into your routine: Exercise multiple times a week to reduce your risk of developing diabetes, which is a major risk factor for ED Exercise multiple times a week to reduce your risk of developing diabetes, which is a major risk factor for ED Eat a balanced diet that’s high in complex carbs, lean proteins, and fibrous vegetables Eat a balanced diet that’s high in complex carbs, lean proteins, and fibrous vegetables Limit foods that can impact heart health and blood pressure, like those high in saturated fat Limit foods that can impact heart health and blood pressure, like those high in saturated fat Quit smoking, which can damage your heart, lungs, and blood vessels, affecting your sexual performance Quit smoking, which can damage your heart, lungs, and blood vessels, affecting your sexual performance Limit your alcohol intake, which can cause “whiskey dick,” a non-clinical term for the negative effects of alcohol on healthy erections Limit your alcohol intake, which can cause “whiskey dick,” a non-clinical term for the negative effects of alcohol on healthy erections You can learn more about maintaining a better lifestyle for your sexual health in our full guide to maintaining an erection naturally. Around 30 to 50 million men in the United States deal with some level of erectile dysfunction. Fortunately, there are many FDA-approved prescription medications that treat ED and other sexual health issues like premature ejaculation. Let’s recap what you should know about sex pills for men: “Sex pills” and penis enlargement pills are readily available, but they’re not all effective.

Recent Posts

Ultimately, there’s no one-size-fits-all pill for sex. You’ll get the best results by using a treatment option that’s right for your needs. Curious about your options for improving your sex life? Get advice from a healthcare provider at Hims today. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. Over-the-counter pills and supplements for sex aren’t backed by the same research as prescription medications. “Sex pills” and penis enlargement pills are readily available, but they’re not all effective. Some OTC options could actually be unsafe. FDA investigations have found that many sex pills for men contain hidden ingredients, including some that can result in dangerous drug interactions and other health problems. FDA-approved medications are your best bet for treating ED. Evidence-based PDE5 inhibitors like sildenafil and tadalafil can help with sexual health issues. They’re also available as chewable ED medications, which contain the same ingredients as Viagra and Cialis in personalized dosages. While they’re not approved for ED or PE, doctors sometimes prescribe SSRIs off-label for sexual dysfunction. Ultimately, there’s no one-size-fits-all pill for sex. You’ll get the best results by using a treatment option that’s right for your needs. Curious about your options for improving your sex life? Get advice from a healthcare provider at Hims today. A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Examining the Hormonal and Vitality Effects of Ashwagandha (Withania somnifera) in Aging, Overweight Males. National Center for Complementary and Integrative Health. Tribulus terrestris versus placebo in the treatment of erectile dysfunction: A prospective, randomized, double blind study. Erectogenic and Neurotrophic Effects of Icariin, a Purified Extract of Horny Goat Weed (Epimedium spp.) In Vitro and In Vivo. Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation?

• Tadalafil is used repeatedly in ED meds to help sustain longer erections.
• Sildenafil provides quick onset effects, useful for spontaneous sexual activity.
• Vardenafil offers similar benefits with a slightly different duration profile.
• Natural supplements like Tribulus terrestris may boost testosterone and desire.
• Fenugreek extract may support libido by increasing testosterone levels.
• Damania (Dynamine) is a supplement targeting mental alertness and sexual arousal.
• L-citrulline boosts nitric oxide, promoting better erections and desire.
• Ashwagandha is an adaptogen that can reduce stress and enhance libido.
• Muira puama is a traditional herb linked to increased sexual activity.
• Zinc supplementation may help restore testosterone levels and libido.
• Niacin (Vitamin B3) can improve blood circulation for better sexual function.
• Sarsaparilla root is used in traditional medicine to boost male libido.

Effect of sildenafil on erectile dysfunction and improvement in the quality of sexual life in China: A multi-center study. Full Name: Lynn Marie Morski, MD, JD Full Name: Lynn Marie Morski, MD, JD Current Role at Hims & Hers: Medical Advisor Current Role at Hims & Hers: Medical Advisor Education: Juris Doctor - Thomas Jefferson School of Law, 2014 Doctor of Medicine - Saint Louis University School of Medicine, 2005 Juris Doctor - Thomas Jefferson School of Law, 2014 Juris Doctor - Thomas Jefferson School of Law, 2014 Doctor of Medicine - Saint Louis University School of Medicine, 2005 Doctor of Medicine - Saint Louis University School of Medicine, 2005 Training: Primary Care Sports Medicine Fellowship - University of Arizona, 2009 Family Medicine Residency - Mayo Clinic - 2008 Primary Care Sports Medicine Fellowship - University of Arizona, 2009 Primary Care Sports Medicine Fellowship - University of Arizona, 2009 Specialties & Areas of Focus: Mental Health, Primary Care, Psychedelic Medicine Previous Work Experience: Physician & Subinvestigator/Clinician Rater - Kadima Neuropsychiatry Institute, January 2025– Investigator - Elite Clinical Network, June 2024– Physician - Veterans Administration, 2010–2019 Physician & Subinvestigator/Clinician Rater - Kadima Neuropsychiatry Institute, January 2025– Physician & Subinvestigator/Clinician Rater - Kadima Neuropsychiatry Institute, January 2025– Invited Commentary on Psychedelic Therapy: A Primer for Primary Care Clinicians.