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Currently, 100mg is the highest dose of sildenafil approved by the FDA (U.S. Food and Drug Administration) for treating erectile dysfunction. Taking a 100mg dose of sildenafil is usually OK if that’s the amount your medical provider tells you to take.

You shouldn’t exceed your provider’s recommended dosage.

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It’s usually safe to take 100mg (milligrams) of sildenafil when your healthcare provider prescribes that dose. Your provider will determine which dose is best for you before they write you a prescription. Often, men will start on a 50mg dose and adjust as needed. Keep reading to learn more about who may benefit from taking 100mg of sildenafil, as well as the potential risks, drug interactions, and other considerations. Sildenafil (with the active ingredient sildenafil citrate) is available in various doses. Your provider will likely only prescribe a 100mg dose if you’ve already tried a lower dose of sildenafil and it hasn’t been effective. The usual starting dose is 50mg, which can be lowered to 25mg. Your healthcare provider may also start treatment for ED with the 100mg dosage if you have severe symptoms. For example, if it’s particularly difficult to get an erection, even with substantial sexual stimulation, or if you’re never able to get an erection.

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A healthcare professional might also consider how often you have sex.

Property Details Dose Range Onset Time Duration
Main Active Ingredient Sildenafil Citrate 50-100mg 30-60 minutes 4-6 hours
Mechanism of Action Inhibits PDE5 enzyme
Absorption Rate Rapid, peaks at about 60 minutes
Metabolism Liver via CYP3A4 enzymes

Your dosage may be adjusted if you have sex frequently and take sildenafil very often — or if you only take this medication sex medicine once every few days for less frequent sexual intercourse. Sildenafil was originally developed to treat angina (chest pain) and hypertension (high blood pressure).

Mechanism of action

Your prescriber can decide if sildenafil (Viagra) is right for you based on the risks and benefits. Some people who took sildenafil (Viagra) had problems with hearing. Sometimes, this happened along with ringing in the ears (tinnitus) and dizziness. It's not clear if these problems are directly related to sildenafil (Viagra). If you notice any changes in your hearing in one or both of your ears, stop taking this medication and call your prescriber right away.

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Risk factors: Taking nitrate medications Taking blood pressure medications Taking alpha blockers Taking certain antifungals or antivirals Taking other ED medications at the same time Sildenafil (Viagra) can interact with certain medications. These drug interactions can raise your risk of side effects, including dangerously low blood pressure. These include nitroglycerin (Nitrostat) and isosorbide dinitrate (Isordil). It can cause your blood pressure to drop too low. Sildenafil (Viagra) can also interact with blood pressure medications.

More common

Other drug interactions are with certain antifungals and antivirals like ritonavir (Norvir). They can raise the risk of side effects like headaches and flushing. It's important to tell your prescriber and best sex pills for women pharmacist about all the medications you take and plan to take. They can make sure all your medications are safe to take together and adjust them to keep you safe if needed. The typical dose is 50 mg taken by mouth about 1 hour before sex, as needed. In the early ‘90s, researchers discovered that it may make an effective treatment for erectile dysfunction. Along with ED, sildenafil has been used off-label as a treatment for: Raynaud’s phenomenon (decreased blood flow to the extremities, causing coldness and numbness) Raynaud’s phenomenon (decreased blood flow to the extremities, causing coldness and numbness) Altitude-induced hypoxemia (lack of sufficient oxygen in the blood in high altitudes) Altitude-induced hypoxemia (lack of sufficient oxygen in the blood in high altitudes) Off-label use is when a drug is prescribed by a licensed healthcare provider to treat something it’s not FDA-approved for — this is legal and common. The dosages of sildenafil are typically different when treating these other health conditions.

Learn more in our sildenafil dosages guide. Sildenafil works well for most men with erectile dysfunction at any dosage.

Risk Factor Potential Consequences Signs of Overuse Prevention Tips
Excessive dosing Increased side effects, hypotension Headache, dizziness, flushing Follow prescribed dose, avoid self-medicating
Frequent use without medical advice Dependence, psychological reliance Anxiety about performance Seek medical guidance before repeated use
Mixing with alcohol or other drugs Increased cardiovascular risk, adverse effects Fainting, chest pain Avoid alcohol, consult doctor if on other meds

However, the highest 100mg dosage produces improvements for a higher percentage of men than 50 or 25mg.

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You can also take it anywhere from 30 minutes to 4 hours before sex. Your dose might be lower if you're an older adult or if you have liver or kidney problems. Your prescriber can also adjust the dose depending on how it works for you and if you have side effects. The maximum recommended dose is 100 mg. GoodRx has partnered with to provide reviews on the different aspects of Sildenafil (Viagra).

Competing interests

Learn more about the effectiveness of Sildenafil (Viagra) based on real life experiences. Based on 14 people taking this medication Based on 28 people taking this medication Based on 34 people who have taken this medication Based on 76 people who have taken this medication Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

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Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. The downside is that 100mg also generally causes more side effects. If you have mild or moderate ED, your healthcare provider will likely prescribe 50mg of sildenafil as your starting dose. This is the typical go-to oral dose for sildenafil — for many men, it’s enough to treat erectile dysfunction and improve sexual performance.

The 100mg dose of sildenafil is generally safe if that’s what your provider prescribed. In some cases, 100mg may be too much. And even those who start on the 50mg dose might go down to 25mg of sildenafil if they’re experiencing unmanageable side effects. In clinical trials, researchers found that 82 percent of men with ED reported some improvements in erectile function after using sildenafil at a dosage of 100mg.

In the same trials, 74 percent and 63 percent of men reported improvements with 50mg and 25mg of sildenafil, respectively. Other clinical trials have suggested that doses above 100mg don’t improve the effectiveness of the medication but do increase side effects. Sildenafil at any dosage takes roughly 30 to 60 minutes to start working, so you should try to take it an hour or so before sexual activity.

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Tell your prescriber about all your health problems and medications you take. Your prescriber can check that sildenafil (Viagra) is safe for you to take. If you take this medication, be very careful getting up after sitting or lying down. This can help prevent you from feeling dizzy from low blood pressure and possibly falling. Risk factors: Medical conditions that affect the penis Sickle cell anemia Multiple myeloma Leukemia It's not common, but some people who took sildenafil (Viagra) have had an erection that lasted more than 4 hours (priapism).

How does sildenafil work (mechanism of action)?

If it's not treated in time, it can lead to permanent damage to your penis. Tell your prescriber about your medical conditions. You're at higher risk of priapism if you have other conditions affecting your penis. The risk might also be higher if you have sickle cell anemia, multiple myeloma, or leukemia. If you have an erection that lasts longer than 4 hours or a painful erection, get medical help right away.

Drug forms and administration

If you suddenly notice changes in your vision in one or both of your eyes, go to the emergency room or call your prescriber right away. Although this is rare, sildenafil (Viagra) might raise the risk of eye damage. This can potentially lead to permanent vision loss. Before starting sildenafil (Viagra), tell your prescriber about your full medical history. If your eye specialist has told you that you have a "crowded" optic disc, you might be at higher risk of vision changes with this medication. That might mean slipping away into the bathroom after you’ve paid the bill or being sneaky on your way back to the car. The point is, you don’t want to take sildenafil 10 minutes before your clothes come off — it needs a little more time to do its thing in your system. Once you take the pill, sildenafil can be effective for 30 minutes to four hours, so you have a little wiggle room for planned sexual activity. But, any longer than four hours, and the concentration in your blood might be too low to have a significant effect on your erection quality. These medications work by inhibiting the PDE5 enzyme, allowing blood vessels in the penis to relax and increasing blood flow to the area.

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Contraindications are blue tablets specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Sildenafil (Viagra) will not be safe for you to take. Taking a nitrate medication for chest pain (angina) Taking guanylate cyclase (GC) stimulators, such as Adempas (riociguat) History of allergic reaction to sildenafil (Revatio) Sildenafil is one of the best-known medications for managing erectile dysfunction (ED) — and not just because it was the first erectile dysfunction drug on the scene back in 1998. Most people are familiar with the brand-name version, Viagra®. But the medication is also sold as a generic drug simply called sildenafil.