20 Mg Vardenafil
The maximum decrease in blood pressure occurred
| Aspect | Description | Typical Dosage | Onset Time | Duration of Action |
|---|---|---|---|---|
| Vardenafil 5 mg | A medication used to treat erectile dysfunction | 5 mg | 30-60 min | Up to 4-5 hours |
| Pharmacological Class | Phosphodiesterase type 5 inhibitor | N/A | N/A | N/A |
| Brand Names | Levitra, Staxyn (dissolvable film) | N/A | N/A | N/A |
between 1 and 4 hours after dosing.
Product Description
This protein binding is reversible and independent of total drug concentrations. Following a single oral dose of 20 mg vardenafil in healthy volunteers, a mean of 0.00018% of the administered dose was obtained in semen 1.5 hours after dosing. Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. The plasma concentration of M1 is approximately 26% that of the parent compound.
More common
This metabolite shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil. Therefore, M1 accounts for approximately 7% of total pharmacologic activity. The total body clearance of vardenafil is 56 L/h, and the terminal half-life of vardenafil and its primary metabolite (M1) is approximately 4-5 hours. After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose). Pediatrics: Vardenafil trials were not conducted in the pediatric population.
Visual disturbances
Geriatrics: In a healthy volunteer study of elderly males (≥65 years) and younger males (18–45 years), mean Cmax and AUC were 34% and 52% higher, respectively, in the elderly males (see PRECAUTIONS, Geriatric Use and DOSAGE AND ADMINISTRATION). Consequently, a lower starting dose of LEVITRA (5 mg) in patients ≥65 years of age should be considered. Renal Insufficiency: In volunteers with mild renal impairment (CLcr = 50-80 ml/min), the pharmacokinetics of vardenafil were similar to those observed in a control group with normal renal function. In the moderate (CLcr = 30-50 ml/min) or severe (CLcr<30 ml/min) renal impairment groups, the AUC of vardenafil was 20–30% higher compared to that observed in a control group with normal renal function (CLcr>80 ml/min). Vardenafil pharmacokinetics have not been evaluated in patients requiring renal dialysis (see PRECAUTIONS, Renal Insufficiency, and DOSAGE AND ADMINISTRATION). Following multiple dosing for
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Original | 100mg | 12 Pills | 72.54€ 69.09€ | |
| Viagra Soft Tabs | 100mg | 30 + 4 Pills | 83.06€ 79.10€ | |
| Kamagra Polo | 100 mg | 120 + 6 Pills | 327.15€ 311.57€ | |
| Cialis Generic | 5mg | 20 Pills | 41.99€ 39.99€ | |
| Viagra Professional | 100mg | 30 Pills | 88.92€ 84.69€ | |
| Levitra Professional | 20mg | 10 Pills | 62.37€ 59.40€ | |
| Kamagra Polo | 100 mg | 60 + 4 Pills | 189.39€ 180.37€ | |
| Cialis Original | 20mg | 8 Pills | 61.70€ 58.76€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Levitra Professional | 20mg | 180 + 4 Pills | 502.31€ 478.39€ | |
| Cialis Original | 20mg | 12 Pills | 78.32€ 74.59€ | |
| Cialis Generic | 2.5mg | 20 Pills | 40.73€ 38.79€ | |
| Apcalis SX Oral Jelly | 20mg | 70 + 7 Sachets | 184.98€ 176.17€ |
31 days, similar blood pressure
| Side Effect | Frequency | Severity | Management Tips |
|---|---|---|---|
| Headache | Common | Mild to Moderate | Hydration, OTC pain relief |
| Flushing | Frequently reported | Mild | Cool environment, calming techniques |
| Nasal congestion | Sometimes | Mild | Decongestants (if advised) |
| Dizziness | Occasionally | Mild | Sit or lie down, avoid driving |
| Upset stomach | Less common | Mild | Take with food, monitor symptoms |
responses were observed on Day 31 as on Day 1.
- Vardenafil 5 mg is used to treat erectile dysfunction in men.
- It works by increasing blood flow to the penis.
- Vardenafil 5 mg usually starts working within 30-60 minutes.
- The typical dosage for Vardenafil 5 mg is once daily.
- It is available by prescription only.
- Vardenafil 5 mg may cause side effects like headache or flushing.
- It is more effective when taken on an empty stomach.
- Alcohol can increase the risk of side effects with Vardenafil.
- Do not take Vardenafil 5 mg with nitrates or certain medications.
- Store Vardenafil 5 mg in a cool, dry place away from children.
- Consult your doctor before starting Vardenafil 5 mg.
- Report any persistent or severe side effects to your doctor.